Francine Gossé Selected Research

lupulon

7/2011	Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells.
2/2011	Early modulation of gene expression used as a biomarker for chemoprevention in a preclinical model of colon carcinogenesis.
10/2010	p53 Activates Either Survival or Apoptotic Signaling Responses in Lupulone-Treated Human Colon Adenocarcinoma Cells and Derived Metastatic Cells.
10/2008	Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells.
7/2007	Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis.

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Francine Gossé Research Topics

Disease

19	Colonic Neoplasms (Colon Cancer) 04/2013 - 01/2002
13	Neoplasms (Cancer) 07/2017 - 11/2003
7	Carcinogenesis 08/2013 - 11/2003
2	Hepatocellular Carcinoma (Hepatoma) 10/2016 - 12/2015
2	Body Weight (Weight, Body) 08/2013 - 07/2012
2	Adenocarcinoma 04/2013 - 08/2006
2	Colorectal Neoplasms (Colorectal Cancer) 10/2011 - 02/2011
2	B-Cell Lymphoma (Lymphoma, B Cell) 02/2011 - 06/2010
2	Leukemia 02/2011 - 06/2010
2	Carcinoma (Carcinomatosis) 07/2005 - 10/2004
1	Rupture 07/2017
1	Liver Neoplasms (Liver Cancer) 07/2017
1	Neoplasm Metastasis (Metastasis) 10/2011
1	Aberrant Crypt Foci 07/2005
1	Aneuploidy (Aneuploid) 10/2004
1	Inflammation (Inflammations) 08/2004

Drug/Important Bio-Agent (IBA)

6	Proanthocyanidins (Procyanidins)IBA 10/2010 - 01/2002
5	AzoxymethaneIBA 08/2013 - 07/2005
5	lupulonIBA 07/2011 - 07/2007
4	Silybin (Lagosa)IBA 04/2013 - 10/2011
4	PolyaminesIBA 12/2006 - 01/2002
3	Death Domain ReceptorsIBA 07/2011 - 07/2007
3	Proteins (Proteins, Gene)FDA Link 02/2011 - 08/2004
2	Drinking WaterIBA 08/2013 - 07/2005
2	DNA (Deoxyribonucleic Acid)IBA 04/2013 - 11/2004
2	TNF-Related Apoptosis-Inducing LigandIBA 08/2012 - 07/2012
2	Matrix Metalloproteinase 7 (Matrilysin)IBA 07/2012 - 06/2010
2	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 07/2012 - 10/2008
2	Lipocalin-2IBA 02/2011 - 06/2010
2	Biomarkers (Surrogate Marker)IBA 02/2011 - 06/2010
2	AcidsIBA 10/2008 - 07/2007
2	cholest-5-en-3 beta,7 alpha-diolIBA 01/2007 - 12/2006
2	EnzymesIBA 12/2006 - 11/2004
2	Polyamine OxidaseIBA 08/2006 - 12/2005
2	MDL 72527IBA 08/2006 - 12/2005
2	PolyphenolsIBA 07/2005 - 11/2003
1	Small Interfering RNA (siRNA)IBA 07/2017
1	Nucleic AcidsIBA 07/2017
1	PolyethyleneimineIBA 07/2017
1	PolymersIBA 07/2017
1	LuciferasesIBA 10/2016
1	Histones (Histone)IBA 04/2013
1	Histone Deacetylase InhibitorsIBA 04/2013
1	Interleukin-1beta (Interleukin 1 beta)IBA 07/2012
1	Caspase 3 (Caspase-3)IBA 07/2012
1	p38 Mitogen-Activated Protein KinasesIBA 07/2011
1	Pharmaceutical PreparationsIBA 02/2011
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2010
1	alpha-DefensinsIBA 06/2010
1	InterleukinsIBA 06/2010
1	LipidsIBA 10/2009
1	FlavonoidsIBA 10/2009
1	procyanidinIBA 08/2006
1	Fluorouracil (Carac)FDA LinkGeneric 11/2004
1	Thymidine KinaseIBA 11/2004
1	geraniol (nerol)IBA 11/2004
1	Volatile Oils (Essential Oils)IBA 11/2004
1	Thymidylate SynthaseIBA 11/2004
1	TubulinIBA 10/2004
1	Paclitaxel (Taxol)FDA LinkGeneric 10/2004
1	Colchicine FDA LinkGeneric 10/2004
1	Interleukin-8 (Interleukin 8)IBA 08/2004
1	AntigensIBA 08/2004
1	PutrescineIBA 11/2003
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2003
1	ResveratrolIBA 11/2003
1	SpermidineIBA 11/2003

Therapy/Procedure

3	Chemoprevention 02/2011 - 09/2006
2	Therapeutics 07/2017 - 10/2008
2	Intraperitoneal Injections 08/2013 - 07/2005
1	Transplantation 10/2016
1	Laparotomy 10/2016
1	Autologous Transplantation 12/2015
1	Oral Administration 07/2012
1	Injections 07/2007